Next-Gen CAR T-CellsPowered by TCR Innovations:Current CAR T-cells, which combine antibody-targeting with T-cell signaling, often cause severe side effects like cytokine release syndrome and struggle in suppressive tumour environments.Recent advances draw on deep insights into T-cell receptor(TCR) biology to enhance CAR design. TCRs, highly sensitive natural receptors, detect minimal antigens with balanced activation. Researchers are now incorporating TCR signaling elements into CARs to create “TCR-like” CARs, which promise more precise activation, lower exhaustion, and better persistence.Early clinical trials of these next-generation CARs show promising results: improved response, fewer side effects, and increased T-cell longevity.With these advances, CAR T-cells could soon offer a powerful, safer option for a broader range of cancers.Regards,JAKSTAR PHARMA