Different Sites of Action and Timing:
Pantoprazole is a proton pump inhibitor (PPI) that acts on the parietal cells in the stomach to reduce acid production. It needs to be absorbed quickly and act systemically before a meal.

Domperidone is a prokinetic agent and dopamine antagonist that works primarily on the upper GI tract to enhance gastric motility and prevent nausea/reflux.

Sustained Prokinetic Effect:
Domperidone in SR form provides a longer duration of action, which helps maintain gastroprokinetic effects throughout the day, especially to counter delayed gastric emptying or reflux that persists after meals.

Improved Symptom Control:
The SR formulation helps reduce dosing frequency (usually once daily), enhances patient compliance, and ensures continuous symptom relief from nausea, bloating, and reflux, which can occur at various times after meals.

Pharmacodynamic Complementation:
While Pantoprazole works best before food intake, Domperidone SR maintains action across postprandial periods, offering better synchronization for managing acid reflux and functional dyspepsia.
Clinical Insight:
This combination, Pantoprazole (immediate release) with Domperidone SR targets both acid suppression and gastric motility in a time-staggered but synergistic manner, offering enhanced therapeutic outcomes in GERD, dyspepsia, and related disorders.
Regards,
JAKSTAR PHARMA.
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