In clinical practice, sedation remains one of the most critical factors influencing a physician’s choice of antihistamines. While first-generation antihistamines like chlorpheniramine and hydroxyzine offer effective symptomatic relief, their CNS-penetrating properties often lead to drowsiness, reduced alertness, and impaired daily functioning.

This becomes especially important when treating:

A)Working professionals

B)Students

C)Drivers and machine operators

D)Elderly patients vulnerable to cognitive decline or falls

As a result, there has been a clear shift toward second generation antihistamines such as levocetirizine, loratadine, desloratadine, and fexofenadine, which are non-sedating or minimally sedating while maintaining efficacy.

Physicians balance the need for rapid relief with patient lifestyle, safety, and compliance making sedation profile a key differentiator in modern antihistamine prescribing.

Understanding this trend is vital for aligning treatment choices with patient-centric care and quality-of-life considerations.

Regards,
JAKSTAR PHARMA