It is a tough spore-forming probiotic that’s been making waves in gut health research.
Bacillus clausii, sometimes called Alkalihalobacillus clausii now, is a rod-shaped bacterium that forms heat-stable spores. That means it survives stomach acid and antibiotics way better than other probiotics. It’s been used since the ‘50s, mainly in products like Enterogermina for digestive issues. It Restores gut balance, especially during or after antibiotics. It crowds out bad bugs, boosts good bacteria, and tweaks the microbiome to fight inflammation. Key strains like O/C, N/R, SIN, and T are the stars , they’re multi-resistant to common antibiotics, so they stick around.
Antibiotic-associated diarrhea (AAD): A 2025 systematic review showed bacillus clausii cuts AAD risk by over 50% at doses around four billion CFUs a day. It also eases nausea, bloating, and tummy pain-super helpful for kids and adults on meds. In Gut infections and diarrherrea a Fresh study from just days ago highlights how it works via the NFκB/Nrf-2/HO-1 pathway to reduce oxidative stress and inflammation in the intestines. Another trial in kids with persistent diarrhea found it speeds recovery and amps up immune markers.As an Immune booster, It strengthens gut barriers and ramps up antibodies. Research from 2024-2025 links it to better resistance against pathogens like Clostridium difficile toxins. Plus the Emerging stuff on growth in animals-pairing it with prebiotics like mannan oligosaccharides improved feed efficiency in piglets. In humans, it’s showing promise for IBS, allergies, and even metabolic tweaks, but more trials needed.
As of late 2025, a Nature paper from August hyped high-dose multi-strain versions (including B. clausii) for enhancing antibiotic treatments by modulating immunity and metabolism. September studies confirmed its probiotic punch in both spore and active forms for food apps. And an October review calls it a success story for the food industry think fortified yogurts or supplements.
Dosing’s usually two to four billion spores daily, safe for most folks, including pregnant peeps and kids.
Side effects are Rare, maybe mild gas at first.
Overall, it’s a reliable player in the probiotic world-solid for gut woes, with fresh research pushing its boundaries.
Regards,
JAKSTAR PHARMA