Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), commonly causes nausea as a gastrointestinal side effect due to its irritation of the stomach lining. This occurs because naproxen inhibits prostaglandins, which normally protect the stomach mucosa, leading to symptoms like nausea, heartburn, or upset stomach in many users. Taking it with food or combining it with domperidone helps mitigate this risk.

Nausea affects up to 10-20% of naproxen users, often alongside vomiting, bloating, or indigestion, especially at higher doses or with prolonged use. These effects are more pronounced than with paracetamol but similar to other NSAIDs like ibuprofen.
Ibuprofen, another NSAID, can irritate the stomach but is less nausea-prone than naproxen in solo use.

Consume naproxen after meals to reduce nausea, and avoid alcohol or lying down immediately after dosing. Persistent nausea warrants medical review to rule out ulcers or bleeding.
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JAKSTAR PHARMA